Our Work

Maternal Overdose Matters Plus (MOMs+)

Epifluence’s maternal overdose prevention program aims to equip birthing hospital clinicians with tools and knowledge, building upon the national AIM patient safety bundle, to provide equitable treatment and recovery access for perinatal patients with opioid and other substance use disorders throughout their pregnancy and postpartum journey.

The MOMs+ program is active in Colorado, Wyoming and Louisiana.

Compass Opioid Provider Safety & Support (OPSS) Program

Funded by CMS in response to the SUPPORT Act, the Compass Healthcare Collaborative has partnered with Epifluence to launch the nationwide Compass Opioid Stewardship Certificate Program, which aims to reduce the opioid epidemic’s impact by equipping clinicians with opioid stewardship knowledge and best practices.

Compass Surgical & Healthcare Alliance for enhanced Recovery and Pain management (SHARP)

The Compass Healthcare Collaborative has partnered with Iowa Health and Human Services and Epifluence to offer perioperative opioid stewardship education and resources to Iowa surgical providers, clinical teams, and patients.

Rural Opioid & addictiOn Treatment System (ROOTS)

ROOTS is a collaborative effort, built and managed by Epifluence, focused on empowering medical systems, hospitals and clinics in rural communities. Through education and coordination with addiction specialists, we provide equitable access to treatment and recovery services for patients with SUDs.

Started in the Eastern Plains of Colorado, ROOTS is dedicated to creating an ecosystem of rural addiction care systems that is effective, accessible, and sustainable. ROOTS is supporting addiction care initiatives in both Colorado and Wyoming.

Epifluence supports The Naloxone Project through data monitoring, analytics, and cross-project collaboration. Our partnership helps advance harm reduction practices by providing actionable insights and fostering alignment across initiatives. For example, we help track naloxone kit distribution across partner sites, identifying trends in usage and gaps in access to ensure timely and equitable distribution. Together, we’re working to enhance impact, improve outcomes, and ensure consistent support for individuals and communities affected by substance use.

The Naloxone Project (TNP)

Opioid Prescribing and Treatment Guidelines

Epifluence clinicians served as editors for both Colorado’s Opioid Solution: Clinicians United to Resolve the Epidemic (CO’s CURE) guidelines and the American College of Emergency Physicians’ (ACEP) 2017 Opioid Prescribing & Treatment Guidelines, helping to shape state and national standards for safe, evidence-based opioid prescribing and pain management

Alternatives to Opioids (ALTO)

Epifluence clinicians have led the effort to promote multimodal analgesia across medical specialties, creating advanced pain management guidelines through the CO’s CURE Initiative, and training hundreds of hospitals and thousands of clinicians nationwide.

Perinatal SUD Video Portfolio

Opioid Stewardship Video Portfolio

Documentaries

This documentary tells the story of the beginning of emergency medicine and how the founders of the specialty changed the American medical landscape.

A palliative care doctor on finding a “good death” for children in the worst situations.

Compass Podcasts

Reports

This final report provides a comprehensive summary of the Colorado ROOTS project, detailing its overall status, key achievements, challenges faced, and outcomes.

It reflects on the project's progress from inception to conclusion, highlighting major milestones reached, significant accomplishments, and lessons learned.

Work with Epifluence.

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